The Use of Light/Chemically Hardened Polymethylmethacrylate, Polyhydroxylethylmethacrylate, and Calcium Hydroxide Graft Material in Combination With Polyanhydride Around Implants and Extraction Sockets in Minipigs: Part II: Histologic and Micro-CT Evaluations
Identifieur interne : 001664 ( Main/Exploration ); précédent : 001663; suivant : 001665The Use of Light/Chemically Hardened Polymethylmethacrylate, Polyhydroxylethylmethacrylate, and Calcium Hydroxide Graft Material in Combination With Polyanhydride Around Implants and Extraction Sockets in Minipigs: Part II: Histologic and Micro-CT Evaluations
Auteurs : Hatice Hasturk [États-Unis] ; Alpdogan Kantarci [États-Unis] ; Mazen Ghattas [États-Unis] ; Smit J. Dangaria [États-Unis] ; Rima Abdallah [Liban] ; Elise F. Morgan [États-Unis] ; Thomas G. H. Diekwisch [États-Unis] ; Arthur Ashman [États-Unis] ; Thomas Van Dyke [États-Unis]Source :
- Journal of periodontology [ 0022-3492 ] ; 2014.
Abstract
This report is the second part of the previously published study on the impact of light/chemical hardening technology and a newly formulated composite graft material for crestal augmentation during immediate implant placement.
A total of 48 implants were placed into the sockets of the mesial roots of freshly extracted mandibular premolar teeth in three minipigs. Crestal areas and intrabony spaces were randomly augmented with light-hardened graft materials including a composite graft consisting of polymethylmethacrylate, polyhydroxylethylmethacrylate, and calcium hydroxide (PPCH) plus polyanhydride (PA); PPCH graft; and PA graft, or left untreated. Distal sockets not receiving implants and the sockets of first molars (n = 60) were randomly treated with one of the graft materials or left empty. In addition, two molar sockets were treated with the original PPCH graft material. Quantitative microcomputed tomography (micro-CT) was used to assess alveolar bone structure and tissue compositions. Histologic evaluations included descriptive histology to assess the peri-implant wound healing, as well as histomorphometric measurements to determine bone-to-implant contact (BIC).
Both trabecular and cortical bone measurements by micro-CT did not reveal any significant differences among the groups. Sites augmented with PPCH+PA resulted in significantly greater BIC surface than PPCH alone and no-graft-treated implants (P <0.05) histologically. Stained ground sections showed complete bone formation between bone and implant surface in the PPCH+PA group, whereas sites without augmentation showed large gaps between bone and implant surfaces, indicating a slower bone apposition and less BIC surface compared to all other groups. Similar to implant sections, all materials showed positive outcome on trabecular and cortical bone formation in extraction sockets with an intact crestal cortical bone.
Histologic evaluations supported the previous findings on implant stability and function and confirmed that PPCH+PA provides a greater BIC with a well-organized implant–bone interface and is useful in crestal augmentation during immediate implant placement.
Url:
DOI: 10.1902/jop.2014.120424
PubMed: 24502615
PubMed Central: 4642446
Affiliations:
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Dangaria</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Oral Biology, Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Oral Biology, Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Abdallah, Rima" sort="Abdallah, Rima" uniqKey="Abdallah R" first="Rima" last="Abdallah">Rima Abdallah</name><affiliation wicri:level="1"><nlm:aff id="A4">Beirut Arab University, Beirut, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>Beirut Arab University, Beirut</wicri:regionArea><wicri:noRegion>Beirut</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Private practice, Beirut, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>Private practice, Beirut</wicri:regionArea><wicri:noRegion>Beirut</wicri:noRegion></affiliation></author><author><name sortKey="Morgan, Elise F" sort="Morgan, Elise F" uniqKey="Morgan E" first="Elise F." last="Morgan">Elise F. 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Diekwisch</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Oral Biology, Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Oral Biology, Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Ashman, Arthur" sort="Ashman, Arthur" uniqKey="Ashman A" first="Arthur" last="Ashman">Arthur Ashman</name><affiliation wicri:level="2"><nlm:aff id="A7">Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York</wicri:cityArea></affiliation></author><author><name sortKey="Van Dyke, Thomas" sort="Van Dyke, Thomas" uniqKey="Van Dyke T" first="Thomas" last="Van Dyke">Thomas Van Dyke</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24502615</idno><idno type="pmc">4642446</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642446</idno><idno type="RBID">PMC:4642446</idno><idno type="doi">10.1902/jop.2014.120424</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002702</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002702</idno><idno type="wicri:Area/Pmc/Curation">002702</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002702</idno><idno type="wicri:Area/Pmc/Checkpoint">001171</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001171</idno><idno type="wicri:Area/Ncbi/Merge">004E21</idno><idno type="wicri:Area/Ncbi/Curation">004E21</idno><idno type="wicri:Area/Ncbi/Checkpoint">004E21</idno><idno type="wicri:doubleKey">0022-3492:2014:Hasturk H:the:use:of</idno><idno type="wicri:Area/Main/Merge">001667</idno><idno type="wicri:Area/Main/Curation">001664</idno><idno type="wicri:Area/Main/Exploration">001664</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Use of Light/Chemically Hardened Polymethylmethacrylate, Polyhydroxylethylmethacrylate, and Calcium Hydroxide Graft Material in Combination With Polyanhydride Around Implants and Extraction Sockets in Minipigs: Part II: Histologic and Micro-CT Evaluations</title><author><name sortKey="Hasturk, Hatice" sort="Hasturk, Hatice" uniqKey="Hasturk H" first="Hatice" last="Hasturk">Hatice Hasturk</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Kantarci, Alpdogan" sort="Kantarci, Alpdogan" uniqKey="Kantarci A" first="Alpdogan" last="Kantarci">Alpdogan Kantarci</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Ghattas, Mazen" sort="Ghattas, Mazen" uniqKey="Ghattas M" first="Mazen" last="Ghattas">Mazen Ghattas</name><affiliation wicri:level="2"><nlm:aff id="A2">Private practice, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Private practice, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Dangaria, Smit J" sort="Dangaria, Smit J" uniqKey="Dangaria S" first="Smit J." last="Dangaria">Smit J. Dangaria</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Oral Biology, Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Oral Biology, Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Abdallah, Rima" sort="Abdallah, Rima" uniqKey="Abdallah R" first="Rima" last="Abdallah">Rima Abdallah</name><affiliation wicri:level="1"><nlm:aff id="A4">Beirut Arab University, Beirut, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>Beirut Arab University, Beirut</wicri:regionArea><wicri:noRegion>Beirut</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Private practice, Beirut, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>Private practice, Beirut</wicri:regionArea><wicri:noRegion>Beirut</wicri:noRegion></affiliation></author><author><name sortKey="Morgan, Elise F" sort="Morgan, Elise F" uniqKey="Morgan E" first="Elise F." last="Morgan">Elise F. Morgan</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Biomedical Engineering, Laboratory of Orthopaedic and Developmental Biomechanics, Boston University, Boston, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Biomedical Engineering, Laboratory of Orthopaedic and Developmental Biomechanics, Boston University, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Diekwisch, Thomas G H" sort="Diekwisch, Thomas G H" uniqKey="Diekwisch T" first="Thomas G. H." last="Diekwisch">Thomas G. H. Diekwisch</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Oral Biology, Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, Chicago, IL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Oral Biology, Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Ashman, Arthur" sort="Ashman, Arthur" uniqKey="Ashman A" first="Arthur" last="Ashman">Arthur Ashman</name><affiliation wicri:level="2"><nlm:aff id="A7">Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York</wicri:cityArea></affiliation></author><author><name sortKey="Van Dyke, Thomas" sort="Van Dyke, Thomas" uniqKey="Van Dyke T" first="Thomas" last="Van Dyke">Thomas Van Dyke</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Applied Oral Sciences, Center for Periodontology, The Forsyth Institute, Cambridge</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of periodontology</title><idno type="ISSN">0022-3492</idno><idno type="eISSN">1943-3670</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">This report is the second part of the previously published study on the impact of light/chemical hardening technology and a newly formulated composite graft material for crestal augmentation during immediate implant placement.</p></sec><sec id="S2"><title>Methods</title><p id="P2">A total of 48 implants were placed into the sockets of the mesial roots of freshly extracted mandibular premolar teeth in three minipigs. Crestal areas and intrabony spaces were randomly augmented with light-hardened graft materials including a composite graft consisting of polymethylmethacrylate, polyhydroxylethylmethacrylate, and calcium hydroxide (PPCH) plus polyanhydride (PA); PPCH graft; and PA graft, or left untreated. Distal sockets not receiving implants and the sockets of first molars (n = 60) were randomly treated with one of the graft materials or left empty. In addition, two molar sockets were treated with the original PPCH graft material. Quantitative microcomputed tomography (micro-CT) was used to assess alveolar bone structure and tissue compositions. Histologic evaluations included descriptive histology to assess the peri-implant wound healing, as well as histomorphometric measurements to determine bone-to-implant contact (BIC).</p></sec><sec id="S3"><title>Results</title><p id="P3">Both trabecular and cortical bone measurements by micro-CT did not reveal any significant differences among the groups. Sites augmented with PPCH+PA resulted in significantly greater BIC surface than PPCH alone and no-graft-treated implants (P <0.05) histologically. Stained ground sections showed complete bone formation between bone and implant surface in the PPCH+PA group, whereas sites without augmentation showed large gaps between bone and implant surfaces, indicating a slower bone apposition and less BIC surface compared to all other groups. Similar to implant sections, all materials showed positive outcome on trabecular and cortical bone formation in extraction sockets with an intact crestal cortical bone.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Histologic evaluations supported the previous findings on implant stability and function and confirmed that PPCH+PA provides a greater BIC with a well-organized implant–bone interface and is useful in crestal augmentation during immediate implant placement.</p></sec></div></front></TEI><affiliations><list><country><li>Liban</li><li>États-Unis</li></country><region><li>Illinois</li><li>Massachusetts</li><li>Texas</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Hasturk, Hatice" sort="Hasturk, Hatice" uniqKey="Hasturk H" first="Hatice" last="Hasturk">Hatice Hasturk</name></region><name sortKey="Ashman, Arthur" sort="Ashman, Arthur" uniqKey="Ashman A" first="Arthur" last="Ashman">Arthur Ashman</name><name sortKey="Dangaria, Smit J" sort="Dangaria, Smit J" uniqKey="Dangaria S" first="Smit J." last="Dangaria">Smit J. Dangaria</name><name sortKey="Diekwisch, Thomas G H" sort="Diekwisch, Thomas G H" uniqKey="Diekwisch T" first="Thomas G. H." last="Diekwisch">Thomas G. H. Diekwisch</name><name sortKey="Ghattas, Mazen" sort="Ghattas, Mazen" uniqKey="Ghattas M" first="Mazen" last="Ghattas">Mazen Ghattas</name><name sortKey="Kantarci, Alpdogan" sort="Kantarci, Alpdogan" uniqKey="Kantarci A" first="Alpdogan" last="Kantarci">Alpdogan Kantarci</name><name sortKey="Morgan, Elise F" sort="Morgan, Elise F" uniqKey="Morgan E" first="Elise F." last="Morgan">Elise F. Morgan</name><name sortKey="Van Dyke, Thomas" sort="Van Dyke, Thomas" uniqKey="Van Dyke T" first="Thomas" last="Van Dyke">Thomas Van Dyke</name></country><country name="Liban"><noRegion><name sortKey="Abdallah, Rima" sort="Abdallah, Rima" uniqKey="Abdallah R" first="Rima" last="Abdallah">Rima Abdallah</name></noRegion><name sortKey="Abdallah, Rima" sort="Abdallah, Rima" uniqKey="Abdallah R" first="Rima" last="Abdallah">Rima Abdallah</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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